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Benzodiazepines do not have any pain-relieving properties themselves, and are generally recommended to avoid in people with ache. However, benzodiazepines corresponding to diazepam can be used for their muscle-relaxant properties to alleviate pain caused by muscle spasms and various dystonias, together with blepharospasm. Tolerance often develops to the muscle relaxant results of benzodiazepines similar to diazepam. Baclofen or tizanidine is sometimes used as an alternative to diazepam. Because of its comparatively long length of action, and proof of safety and efficacy, diazepam is preferred over other benzodiazepines for therapy of individuals experiencing moderate to severe alcohol withdrawal. An exception to that is when a drugs is required intramuscular during which case either lorazepam or midazolam is beneficial.
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It’s additionally used in hospital to reduce alcohol withdrawal symptoms, corresponding to sweating or problem sleeping. The benzodiazepines gained popularity among medical professionals as an improvement over barbiturates, which have a comparatively slim therapeutic index, and are far more sedative at therapeutic doses. The benzodiazepines are also far much less harmful; dying rarely results from diazepam overdose, except in circumstances where it is consumed with large quantities of other depressants . Benzodiazepine drugs such as diazepam initially had widespread public assist, however with time the view modified to one of rising criticism and calls for restrictions on their prescription. Diazepam is very lipid-soluble, and is extensively distributed throughout the physique after administration. It easily crosses both the blood–brain barrier and the placenta, and is excreted into breast milk.
When benzodiazepines are used, withdrawal signs might develop when switching to a benzodiazepine with a considerably shorter half-life. Concentrations of diazepam in milk are 10% of these in maternal blood. Normalised for body weight, roughly 5% of the mom’s dose reaches the infant.
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Anxiety or rigidity related to the stress of everyday life usually doesn’t require treatment with an anxiolytic. In acute alcohol withdrawal, Valium may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis. Valium is a prescription medication used to deal with signs of anxiety, muscle spasm, alcohol withdrawal and as a sedative before surgical procedure or to treat seizures.